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'Superheroes': Coronavirus survivors donate plasma hoping to heal the sick
Diana Berrent was the first coronavirus survivor in New York state to get screened hoping to donate anti-body rich plasma.
AFP

'Superheroes': Coronavirus survivors donate plasma hoping to heal the sick

Maggy Donaldson (Agence France-Presse) - April 3, 2020 - 2:37pm

NEW YORK, United States — As she emerges from quarantine, recovered COVID-19 patient Diana Berrent is eager to join the battle against the pandemic and donate precious antibodies that researchers hope might help others.

In mid-March, the New Yorker woke up with a 102-degree (39 Celsius) fever and intense chest heaviness, becoming one of the first from her Long Island neighborhood to test positive for coronavirus.

This week, Berrent was the first survivor in her state screened for antibodies — immune system-generated proteins that can ward off viruses -—to contribute to initial tests seeking treatment for the infection that's left more than 51,000 people dead worldwide.

Convalescent plasma, the fluid in blood teeming with antibodies post-illness, has proven effective in small studies to treat infectious diseases including Ebola and SARS.

Now, the US Food and Drug Administration has greenlit physicians to experiment with the strategy as coronavirus patients fill hospitals and the nation's positive caseload spikes to over 236,000.

Bruce Sachias, chief medical officer of the New York Blood Center — which will collect, test and distribute donations in the city — said while there is reason to believe plasma transfusions can help alleviate the current crisis, tests underway are not intended to yield golden-ticket solutions.

"It's really important for us to be very cognizant of the fact that we're still in very new territory," he said.

Crisis mode

Eldad Hod and Steven Spitalnik — transfusion medicine doctors leading trials at Columbia University's Irving Medical Center — are cautiously optimistic but, like Sachias, emphasize the unknowns.

Spitalnik told AFP they believe "within seven to 14 days after the onset of an infection, that people will develop an immune response and eventually make high amounts of antibodies -- although exactly when the peak of antibody production will be, we don't know."

He said some data suggests antibody production could peak around 28 days post-infection, and hopes the new research could provide a clearer picture.

Hod said each donation "can potentially save three to four lives."

The primary goal now is acquiring a significant plasma stock, so researchers can conduct formal studies with control groups who would receive non-convalescent plasma, and others the antibody-packed donations.

Initial plasma, however, will be distributed for "compassionate use," Hod said — to patients outside studies but for whom other strategies have failed. 

They also aim to test treatments on already-hospitalized patients and as a preventative therapy in settings like nursing homes.

Spitalnik said that normally they would want "highly controlled" clinical trials, which take longer but are more definitive.

But "this is a crisis," he said. 

"We understand and we are amenable to doing things that will take shorter amounts of time — but hopefully we'll yield at least some rigorous results."

Internal hazmat suit

Berrent is eager to open her personal blood bank and crossing her fingers in hope the process can prove life-saving.

"We can be superheroes," the 45-year-old photographer told AFP.

"These are unprecedented, frightening times where everything is beyond our control — except for we as survivors can help," Berrent said.

"We can be the ones running towards the fire in our own internally built hazmat suit. And that is a tremendous opportunity — how could you not take advantage of that?"

Berrent's antibody levels met donation requirements — but she is waiting on results of a nasal swab test to make sure any remnants of coronavirus have dissipated.

In the meantime, she's started the more than 17,000-member Facebook group "Survivor Corps" to mobilize other survivors to share their immunity.

"I can't wait to donate," Berrent said. "We need a forward-looking solution-based approach that offers hope because things are very, very bleak right now."

'Science will win'

A Houston hospital has already transfused plasma from a recovered patient into someone critically ill, though it's still too early to determine efficacy.

Sachias said hundreds of people who believe they have recovered from COVID-19 have applied to help in New York, the US epicenter of the highly contagious virus that accounts for nearly half of related deaths stateside.

As their research gets underway, Hod said one silver lining of coronavirus' global scale has been the boost to collaborative scientific efforts, saying data is being shared more openly than ever before.

"I think a lot of the scientific community has tried to put their egos aside... and banded together to try and work together for the common good," he said. 

"And I think in the end, science will win."

NOVEL CORONAVIRUS
As It Happens
LATEST UPDATE: March 8, 2021 - 8:53pm

Follow this page for updates on a mysterious pneumonia outbreak that has struck dozens of people in China.

March 8, 2021 - 8:53pm

Syrian President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after experiencing mild symptoms, the presidency says Monday.

"After experiencing mild symptoms that resemble... COVID-19, President al-Assad and first lady Asma Al-Assad took a PCR test, and the result showed that they are infected with the virus," the presidency said in a statement.

"They are in good health and their condition is stable," the statement added. — AFP

March 8, 2021 - 12:34pm

Children return to school in England on Monday for the first time since January, as the government begins to ease tough restrictions thanks to a mass vaccination drive against the coronavirus.

Throughout the latest lockdown since the start of the new year, schools have remained open to children of key workers and the most vulnerable.

But all other youngsters have been at home, causing a headache for working parents, and fears about the effect on their learning. — AFP

March 7, 2021 - 10:52am

South Korea and the United States will conduct their annual military training this week but the drills will be smaller because of COVID-19, Seoul says.

The nine-day exercise that begins Monday is still likely to infuriate the North, which has long considered them rehearsals for invasion.

"The upcoming annual training is a computer-simulated command post exercise that is strictly defensive in nature," the Joint Chiefs of Staff says in a statement, adding they went ahead with plans after considering the pandemic. — AFP

March 6, 2021 - 11:37am

The US Senate broke a logjam late Friday when a centrist Democrat compromised on a key provision of the Covid relief package, setting the $1.9 trillion bill on a likely path to passage.

Democrats had struggled to keep Senator Joe Manchin's support for expanded unemployment aid in the sprawling measure, and he threatened to side with Republicans in the evenly divided chamber.

But the deal, which reduced the jobless benefits, kept Manchin on board and allowed action to resume in the Senate as it navigates toward passage of President Joe Biden's top legislative priority sometime this weekend.

Manchin, keen on more fiscal restraint than was evident in the Biden package, was flexing his political muscle, balking at an amendment that would increase weekly additional unemployment benefits from $300 to $400, and extending them through August. — AFP

March 5, 2021 - 4:02pm

The Philippines records 3,045 new coronavirus infections Friday—the highest single day rise since mid-October, pushing the country’s caseload to 587,704.

The department also records 178 new recoveries and 19 more fatalities, bringing the total of survivors to 535,207 and the death toll to 12,423, respectively.

Active cases in the country are at 40,074 or 6.8% of the total cases.

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