AUTHORS
Charles C. Chante MD
Charles C. Chante MD
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Long-acting Beta2 agonists didn’t boost BP in COPD
by Charles C. Chante MD - December 8, 2019 - 12:00am
Neither heart rate nor blood pressure worsened under long-term use of long-acting beta2 agonists olodaterol or formoterol in patients with chronic obstructive pulmonary disease, according to a post hoc pooled analysis...
‘Undetectable’ HIV means ‘untransmissible’ confirmed in larger sex study
by Charles C. Chante MD - December 1, 2019 - 12:00am
One maxim of current HIV management is U=U; Undetectable equals Untransmissible, and it received new backing for the specific question of whether HIV treated to an undetectable level can transmit from a man who engages...
Next-gen sputum PCR panel boosts CAP diagnostics
by Charles C. Chante MD - November 24, 2019 - 12:00am
A next-generation lower respiratory tract sputum polymerase chain reaction film array panel identified etiologic pathogens in 100 percent of a group of patients hospitalized for community-acquired pneumonia.
Rising US PrEP use linked with dropping HIV infections
by Charles C. Chante MD - November 17, 2019 - 12:00am
Pre exposure prophylaxis against HIV infection by US residents appears to be paying off: The number of new US HIV infections among those at least 13 years old dropped during 2012-2016, and this decline showed a statistically...
Statin use is uniformly in adults with dyslipidemia disorders
by Charles C. Chante MD - November 10, 2019 - 12:00am
Only half of adults with familial hypercholesterolemia are currently in statin therapy, with even fewer receiving a high-intensity statin, according to an analysis of data from the National Health and Nutrition Examination...
Breast arterialcalcification low bonemass predicted CAD in women
by Charles C. Chante MD - November 3, 2019 - 12:00am
Breast arterial calcification and low bone mass were strongly linked to risk of coronary artery disease in asymptomatic women, according to cross-sectional registry study.
USPSTF: Insufficient evidence for ankle-branchial index screening
by Charles C. Chante MD - October 27, 2019 - 12:00am
There’s not enough evidence to recommend – or not recommend – routine ankle-brachial index screening for peripheral artery disease in asymptomatic adults without known cardiovascular or chronic...
EULAR recommendations on steroids: ‘As necessary but as little as possible’
by Charles C. Chante MD - October 20, 2019 - 12:00am
Glucocorticosteroids remain an important therapeutic option for many patients with rheumatic and nonrheumatic disease, but careful assessment of their relative benefits and risks needs to be considered when prescribing,...
How to prioritize CV risk reduction in type 2 diabetes
by Charles C. Chante MD - October 13, 2019 - 12:00am
The pooled analysis showed that initiation of SGLT2 inhibitors was associated with a significantly lower risk of heart failure events, compared with other glucose-lowering drugs (risk ration, 0.61; P less than .001.)....
How to prioritize CV risk reduction in type 2 diabetes
by Charles C. Chante MD - October 6, 2019 - 12:00am
In the opinion of a doctor, the paradigm of treating patients with type 2 diabetes should shift from a narrow focus on hemoglobin A control to a broader strategy of reducing cardiovascular risk.
Failure to prevent most heart failure could be avoided
by Charles C. Chante MD - September 29, 2019 - 12:00am
Until the randomized EMPA-REG-OUTCOME trial of the sodium-glucose transporter 2 (SGLT-2) inhibitors empagliflozin (Jardiance), no glucose-lowering drug available for treatment of type 2 diabetes had shown any benefit...
Failure to prevent most heart failure could be avoided
by Charles C. Chante MD - September 22, 2019 - 12:00am
More than 960,000 new cases of heart failure will occur in the United States this year – and most of them could have been prevented, asserted at Annual Cardiovascular Conference.
Long-term effects of using ketamine for depression are uncertain
by Charles C. Chante MD - September 15, 2019 - 12:00am
Low doses of ketamine, an N- methyl- D- aspirate glutamate receptor antagonist, can produce benefits that are unprecedented in the history of treating major depression.
Ledipasvir/Sofosbuvir looks good in HBV-coinfected patients
by Charles C. Chante MD - September 8, 2019 - 12:00am
For patients with chronic hepatitis C and hepatitis B virus co-infection, 12 weeks of ledipasvir/sofosbuvir therapy achieved a 100 percent sustained viral response rate without causing liver failure or death in a...
Case for rivaroxaban and aspirin for pad gets stronger
by Charles C. Chante MD - September 1, 2019 - 12:00am
Combination treatment with aspirin and low dosage of the anticoagulant rivaroxaban has a broader benefit for reducing adverse events in patients with peripheral artery disease than initially reported from the COMPASS...
No short-term link found between PPIs, heart attack
by Charles C. Chante MD - August 25, 2019 - 12:00am
Proton pump inhibitor conferred no short-term increase in risk for myocardial infarction in a large retrospective insurance claims study.
Diabetes – high rate of med discontinuation requires vigilance
by Charles C. Chante MD - August 18, 2019 - 12:00am
Most patients with type 2 diabetes mellitus stop taking their medication within a year, and nearly one-third stop within the first 3 months, a retrospective analysis of claims data for more than 324,000 patients...
ACIP unanimously recommends new hepatitis B vaccine
by Charles C. Chante MD - August 11, 2019 - 12:00am
At a meeting of the Center for Disease Control and Prevention’s advisory committee on immunization practices, members unanimously voted to include HEPLISAV-B on the ACIP list of recommended products to vaccinate...
Aspirin may protect against dementia in type 2 diabetes
by Charles C. Chante MD - August 4, 2019 - 12:00am
Daily low-dose aspirin reduce the incidence of dementia by more than one-third in patients with type 2 diabetes mellitus in the randomized JPAD 2 study.
Head injury linked to amyloid deposition decades later
by Charles C. Chante MD - July 28, 2019 - 12:00am
A history of head injury is associated with increased amyloid deposition in the brain, both globally and in the frontal cortex, according to PET imaging in 329 older adults without dementia.
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